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KMID : 1199120080320020157
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Korean Diabetes Journal
2008 Volume.32 No. 2 p.157 ~ p.164
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The Biochemical Markers of Coronary Heart Disease Correlates Better to Metabolic Syndrome Defined by WHO than by NCEP-ATP 3 or IDF in Korean Type 2 Diabetic Patients
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Lim Dong-Mee
Park Keun-Young
Koh Gwan-Pyo
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Abstract
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Background: Metabolic syndrome (MetS) is constellation of cardiovascular risk factors. There are three typically used definitions of MetS proposed by WHO, IDF and NCEP-ATP III. We conducted this study to compare the associations of MetS by WHO, IDF and NCEP-ATP III definition to various metabolic markers of coronary heart diseases in Korean type 2 diabetes patients.
Methods: We enrolled 151 Korean type 2 diabetes patients in one hospital. Anthropometric and biochemical parameters, including high-sensitivity C-reactive protein (hsCRP), homocysteine, uric acid were measured. And then, we divided MetS group from non-MetS group according to three other definitions.
Results: Serum hsCRP level was higher in those with MetS group than non-MetS group by WHO definition (0.33 ± 0.36 mg/dL vs 0.18 ± 0.26 mg/dL, P < 0.001). But, there are no difference in MetS group and non-MetS group by IDF and NCEP-ATPIII definition. (By IDF, 0.28 ± 0.31 mg/dL vs 0.25 ± 0.34 mg/dL, P = 0.64; By NCEP-ATP III, 0.28 ± 0.33 mg/dL vs 0.22 ± 0.32 mg/dL, P = 0.41). Uric acid and homocysteine levels were higher in those with MetS by WHO definition (P < 0.05). Similarly, analyses according to IDF and NCEP ATP III definition showed no significant difference.
Conclusion: In conclusion, WHO definition of MetS has a stronger relationship with the biochemical markers of coronary heart disease in Korean type 2 diabetes patients. (KOREAN DIABETES J 32:157~164, 2008)
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KEYWORD
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Cardiovasculardisease, Diabetesmellitus, Metabolicsyndrome
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